Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides
نویسندگان
چکیده
منابع مشابه
Synthesis and anticancer activity of glucosylated podophyllotoxin derivatives linked via 4β-triazole rings.
A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using MTT assays. Most of these triazole derivatives have good anticancer activity. Among them, compound...
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A series of novel perbutyrylated glycosides of 4β-triazolopodophyllotoxin derivatives were synthesized by utilizing the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. Evaluation of cytotoxicity against a panel of five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using the MTT assay shows that some of these glycosylated derivatives have good anticancer activity....
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ژورنال
عنوان ژورنال: Natural Products and Bioprospecting
سال: 2015
ISSN: 2192-2195,2192-2209
DOI: 10.1007/s13659-015-0057-3